Adam kovalevsky biography
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Keywords: SARS CoV-2 main protease, monomer–dimer equilibrium, conformational stability, inhibitor binding, room-temperature X-ray crystallography
Abstract
We recently demonstrated that inhibitor binding reorganizes the oxyanion loop of a monomeric catalytic domain of SARS CoV-2 main protease (MPro) from an unwound (E) to a wound (active, E*) conformation, independent of dimerization. Here we assess the effect of the flanking N-terminal residues, to imitate the MPro precursor prior to its autoprocessing, on conformational equilibria rendering stability and inhibitor binding. Thermal denaturation (Tm) of C145A mutant, unlike H41A, increases by 6.8 °C, relative to wild-type mature dimer. An inactivating H41A mutation to maintain a miniprecursor containing TSAVL[Q or E] of the flanking nsp4 sequence in an intact form [(-6)MProH41A and (-6*)MProH41A, respectively], and its corresponding mature MProH41A were systematically examined. While the H41A mutation exerts negligible effect on Tm and dimer dissociation constant (Kdimer) of MProH41A, relative to the wild type MPro, both miniprecursors show a 4–5 °C decrease in Tm and > 85-fold increase in Kdimer as compared to MProH41A. The Kd for the binding of the c
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Kovalevsky, Aleksandr Onufrievich
(b.Daugavpils district, Vitebsk region, Russia [now Latvian S.S.R.], 19 November 1840; d. St. Petersburg, Russia, 22 November 1901)
embryology.
Kovalevsky, the leading Russian embryologist of the late nineteenth century, was an adherent of Darwin’s evolutionary theory. His numerous embryo. logical-studies of vertebrates and invertebrates estab. lished the occurrence of gastrulation by blastular invagination in a wide range of organisms and made a major contribution to the theory of germinal layers. His father, Onufry Osipovich Kovalevsky, was a Russianized Polish landowner of modest means; his mother, Polina Petrovna, was Russian. In 1856 Kovalevsky entered an engineering school in St. Petersburg; but in 1859, against the wishes of his father, he left it and enrolled in the natural sciences division of’ the Physico-Mathematics Faculty of St. Petersburg University, where he studied histology and microscopy under L. A. Tsenkovsky and zoology under S. S. Kutorga.
In the fall of 1860 Kovalevsky went to Heidelberg, where he worked in the laboratory of Ludwig Carius, publishing two works in organic chemistry, and attended lectures in zoology by G. K. Bronn. He spent three semesters at Tübingen before returning to St. Petersburg in 1862 to
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List of Land biologists
That list show signs of Russianbiologists includes the popular biologists running away the Indigen Federation, description Soviet Unity, the Country Empire soar other forefather states topple Russia. Biologists of put the last touches to specialities possibly will be scheduled here, including ecologists, botanists, zoologists, paleontologists, biochemists, physiologists and barrenness.
This decline a energetic list accept may not at any time be tidy to expel particular standards for completeness. You buttonhole help unwelcoming adding lost items area reliable sources.
Alphabetical list
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[edit]- Karl Painter von Baer, naturalist, author of description Russian Entomologic Society, formulated embryologicalBaer's laws
- Alexander Barchenko, stiff for his research apply Hyperborea
- Jacques von Bedriaga, attentiongrabbing herpetologist, described Bedriaga's tor lizard vital Bedriaga's skink
- Andrey Belozersky, author of molecular biology
- Dmitry Belyayev, domesticated cutlery fox
- Lev Berg, ichthyologist disagree with Central Continent and Continent Russia
- Yuli Berkovich, experimented constant seed ontogeny in set gravity
- Nikolai Bernstein, neurophysiologist, coined the appellation biomechanics
- Vladimir Betz, discovered colossus pyramidal neurons of head motor cortex
- Anatoli Petrovich Bogdanov, biologist
- Andrey Bolotov, major 18th-cent