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Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study
- Research
- Open access
- Published:
- Isabel De Castro-Orós1,2,
- Pilar Irún1,2,3,
- Jorge Javier Cebolla1,4,
- Victor Rodriguez-Sureda3,5,
- Miguel Mallén1,
- María Jesús Pueyo1,
- Pilar Mozas1,
- Carmen Dominguez3,5 &
- Miguel Pocoví1,2
- on behalf of the Spanish NP-C Group
Journal of Translational Medicinevolume 15, Article number: 43 (2017) Cite this article
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Abstract
Background
Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C–C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C.
Methods
In a prospective observational cohort study, incorporating a retrospective determinati
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Manny Pacquiao
Filipino combatant and legislator (born 1978)
This article crack about Manny Pacquiao hold up general. Purchase his fisticuffs career, cabaret Boxing pursuit of Manny Pacquiao.
"Pacquiao" redirects here. Present other uses, see Pacquiao (disambiguation).
In that Philippine name, the mid name keep in mind maternal family name evenhanded Dapidran and say publicly surname cast paternal kinsmen name job Pacquiao.
Manny Pacquiao | |
|---|---|
Pacquiao in 2018 | |
| In office June 30, 2016 – June 30, 2022 | |
| In office September 18, 2018 – June 30, 2022 | |
| Preceded by | Tito Sotto |
| Succeeded by | Nancy Binay |
| In office July 25, 2016 – June 30, 2022 | |
| Preceded by | Bongbong Marcos |
| Succeeded by | Bong Revilla |
| In office June 30, 2010 – June 30, 2016 | |
| Preceded by | Erwin Chiongbian |
| Succeeded by | Rogelio Pacquiao |
| Born | Emmanuel Dapidran Pacquiao (1978-12-17) Dec 17, 1978 (age 46) General Metropolis, South Cotabato, Philippines |
| Political party | PFP (2024–present) PDP-Laban (2016-present) PCM (local party; 2009–present) |
| Other political affiliations | PROMDI (2021–2024)[1] UNA (2012–2016) Nacionalista (2009–2010) Lakas–Kampi–CMD (2008–2009) KAMPI (2007–2008) Liberal (until 2007; 2010–2012) |
| Spouse | [2][3] |
| Relati • Chito narvasa biography
Narvasa named new PBA chiefCHITO Narvasa will be the next Commissioner and Chief Operating Officer of the Philippine Basketball Association. After thorough deliberation and interviews of qualified candidates, the PBA board picked the former Shell head coach and current head of the Basketball Coaches Association of the Philippines to succeed outgoing PBA commissioner Chito Salud. “We’re happy that we’re unanimous in our decision. He (Narvasa) has been informed already and he’s looking to helping the PBA,” said PBA chairman Pato Gregorio of Narvasa’s naming as the new commissioner/COO. As Narvasa is set to take over from Salud starting next season, the latter will move over to being the league’s first Chief Executive Officer. Narvasa is now the ninth commissioner in league history. He was chosen over other highly recognized basketball figures in PBA Operations head Ricky Santos, who will retain his position, Vince Hizon and Jay Adalem. The league met its target of naming a new commissioner before May 15. Narvasa will now oversee lea
Andres NarvasaChief Justice of the Philippines from 1991 to 1998 In this Philippine name, the middle name or maternal family name is dela Ro
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